Sulfation of Estradiol in Human Epidermal Keratinocyte

Isolation and Cultivation of Adult Human Keratinocyte Stem Cells for Regeneration of Epidermal Sheets

Background: Keratinocyte stem cell is one of the adult stem cells that inhabits the skin and contributes to skin function and renewal. Adult stem cells are best defined by their capacity to self-renew, and to maintain tissue function for a long period of time. These findings indicate the importance of these cells for clinical applications including regenerative medicine, tissue engineering and ...

isolation and cultivation of adult human keratinocyte stem cells for regeneration of epidermal sheets

background: keratinocyte stem cell is one of the adult stem cells that inhabits the skin and contributes to skin function and renewal. adult stem cells are best defined by their capacity to self-renew, and to maintain tissue function for a long period of time. these findings indicate the importance of these cells for clinical applications including regenerative medicine, tissue engineering and ...

Role for WNT16B in human epidermal keratinocyte proliferation and differentiation.

WNT signalling regulates a variety of cell functions including cell fate, polarity, and differentiation via the canonical or beta-catenin stabilisation pathway and/or the planar cell polarity or non-canonical pathway. We have previously demonstrated that two isoforms (A and B) from the WNT16 locus have differential expression in various adult human tissues. In this study we show that WNT16B but...

Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation.

Human skin is maintained by the differentiation and maturation of interfollicular stem and progenitors cells. We used DeepCAGE, genome-wide profiling of histone modifications and retroviral integration analysis, to map transcripts, promoters, enhancers, and super-enhancers (SEs) in prospectively isolated keratinocytes and transit-amplifying progenitors, and retrospectively defined keratinocyte ...

Epidermal Keratinocyte CD1d Expression Ceramide-Dependent Regulation of Human